Phosphorus-containing hmg-coa reductase inhibitors, new...

Details Phosphorus-containing hmg-coa reductase inhibitors, new... Phosphorus-containing hmg-coa reductase inhibitors, new...

C - Chemistry, Metallurgy

07

F

C07F 9/572 (2006.01) A61K 31/675 (2006.01) C07D 207/32 (2006.01) C07D 207/33 (2006.01) C07D 207/333 (2006.01)

Patent

CA 2043525

HX10c Abstract PHOSPHORUS-CONTAINING HMG-CoA REDUCTASE INHIBITORS AND METHOD Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure Image wherein R is OH, or salts thereof ox lower alkoxy; Rx is H or alkyl; R1 is lower alkyl; R2 is lower alkyl; R3 is phenyl or substituted phenyl; and R4 is phenyl or substituted phenyl. New pharmaceutical compositions containing such compounds especially oral dosage forms, and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.

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