In situ gelling systems as sustained delivery for front of eye

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 9/08 (2006.01)

Type

Patent

Patent number

CA 2726502

Description

An ophthalmic formulation particularly well suited for use as a delivery vehicle in the sustained delivery of ophthalmic active agents to the eye. The formulations comprise an alginate, wherein the guluronic acid content is in a range of about 35 percent to about 45 percent, and an excipient, preferably gellan gum or scleroglucan, with an active agent dissolved or suspended therein that together provide an in situ-gelling system for use in the eye.

La présente invention concerne une formulation ophtalmique particulièrement bien appropriée à une utilisation en tant que véhicule d'administration lors de l'administration soutenue d'agents actifs ophtalmiques à l'il. Les formulations comprennent un alginate, dans lequel la teneur en acide guluronique se situe dans une plage comprise entre environ 35 pour cent et environ 45 pour cent, et un excipient, de préférence la gomme gellane ou le scléroglucane, comprenant un agent actif dissous ou en suspension dans celle-ci, qui forment ensemble un système formant un gel in situ pour une utilisation dans l'il.

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