Antigen binding polypeptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/00 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2728076

The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire of species in the family Camelidae, and to anti-gen binding polypeptides obtained using this technology platform. In particular, the invention provides an antigen binding polypeptide comprising a VH domain and a VL domain, wherein at least one hypervariable loop or complementarity determining region (CDR) in the VH domain or the VL domain is obtained from a VH or VL domain of a species in the family Camelidae.

Linvention concerne une plate-forme technologique pour la production de polypeptides de liaison aux antigènes présentant une spécificité pour un antigène cible donné qui est basé sur le répertoire danticorps classique despèces de la famille Camelidae, ainsi que des polypeptides de liaison aux antigènes, obtenus au moyen de cette plate-forme technologique. Linvention concerne en particulier un polypeptide de liaison aux antigènes comprenant un domaine VH et un domaine VL, au moins une boucle hypervariable ou une zone de définition de complémentarité (CDR) dans le domaine VH ou le domaine VL étant obtenue à partir dun domaine VH ou VL dune espèce de la famille Camelidae.

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