Immunogenic formulations of variable peptidic epitopes and...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 31/18 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C07K 17/02 (2006.01) C07K 17/06 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2472265

A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hypervariable epitope construct (HEC). Immunization with a HEC evokes broadly reactive immunity against divergent strains of a pathogen upon which the HEC is based.

La présente invention concerne un procédé qui permet de préparer un mélange de peptides immunogéniques en une seule synthèse. Le mélange de peptides de l'invention constitue une représentation collective de la variabilité in vivo observée dans les épitopes immunogéniques d'un pathogène. Le mélange de l'invention a été baptisé construction d'épitopes hypervariables (HEC). L'immunisation par le mélange HEC précité entraîne une large immunité réactive contre des souches divergentes d'un pathogène sur lequel ledit mélange HEC est basé.

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