Diastereoisomers of 4-hydroxyisoleucine and uses thereof

Details Diastereoisomers of 4-hydroxyisoleucine and uses thereof Diastereoisomers of 4-hydroxyisoleucine and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 229/22 (2006.01) A61K 31/198 (2006.01) A61P 3/10 (2006.01) C07D 307/32 (2006.01)

Patent

CA 2598491

The invention relates to configurational isomers 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The isomers of the invention exhibit insulinotropic activity and thus may be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.

L'invention concerne des isomères configurationnels 4-hydroxyisoleucine, ainsi que des lactones, des sels pharmaceutiquement acceptables, des promédicaments associés, des procédés de préparation et des compositions pharmaceutiques les contenant. Les isomères de l'invention possèdent une activité insulinotropique et peuvent donc être utiles à la prévention et au traitement de troubles du métabolisme des glucides ou des lipides, y compris le diabète sucré (diabètes de type 1 et de type 2), le prédiabète, et le syndrome métabolique.

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