Substituted pyrimidine compounds and their use

Details Substituted pyrimidine compounds and their use Substituted pyrimidine compounds and their use

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 239/42 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2274063

Selected novel substituted pyrimidine compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds of the following general formula: (see above formula) analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

La présente invention concerne de nouveaux composés pyrimidines substitués efficaces en prophylaxie et en traitement contre des affections telles que les affections à médiation du TNF- alpha , de l'IL-1 beta , de l'IL-6 et/ou de l'IL-8, et contre des états pathologiques tels que la douleur et le diabète. L'invention, qui concerne également de nouveaux composés et certains de leurs analogues, de leurs promédicaments et de leurs sels pharmaceutiquement acceptables, concerne aussi des compositions pharmaceutiques et des procédés convenant à la prophylaxie et au traitement d'affections, d'états pathologiques ou d'états caractérisés par des phénomènes inflammatoires, algiques, diabétiques et similaires. L'invention concerne enfin des procédés de fabrication de tels composés ainsi que des intermédiaires intervenant dans de tels procédés.

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