1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as...

Details 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as... 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as...

C - Chemistry, Metallurgy

07

D

167/235, 260/303

C07D 413/12 (2006.01) A61K 31/42 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2022425

Compounds of the formula (See formula I) wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl of 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl, lower-alkoxy, nitro, lower-alkoxycarbonyl or trifluo- romethyl; and R8 is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when R8 is hydrogen R' is hydroxy-lower-alkyl, are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.

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