Phosphonic acid derivatives, production and use thereof

Details Phosphonic acid derivatives, production and use thereof Phosphonic acid derivatives, production and use thereof

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/55 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2071106

TITLE: PHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND USE ABSTRACT A phosphonic acid derivative compound represented by formula [I] or a pharmaceutically acceptable salt thereof: Image [I] wherein R1, R2 and R3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R2 is unsubstituted methyl, (2) R3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R1 is benzyloxycarbonylaminomethyl, R2 is isobutyl and R3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.

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