Tms1 compositions and methods of use

Details Tms1 compositions and methods of use Tms1 compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2386476

The invention relates to the identification of a novel gene, TMS1, which is transcriptionally silenced as a result of methylation. Nucleic acids and polypeptides are provided as are methods and tools for diagnosing and treating disorders characterized by such methylation, and/or abnormally low levels of TMS1 expression products.

L'invention concerne l'identification d'un nouveau gène, baptisé gène TMS1, qui est transcriptionnellement réduit au silence du fait d'une méthylation. L'invention concerne également des acides nucléiques et des polypeptides, ainsi que des procédés et des outils pour le diagnostic et le traitement de troubles caractérisés par une telle méthylation ou de niveaux anormalement bas de produits d'expression du gène TMS1.

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