C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/497 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2598459
The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt, solvate or ester thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, zenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
L'invention concerne un composé, ou des énantiomères, stéréoisomères, rotamères, tautomères, racémates ou un promédicament de ce composé, ou des sels pharmaceutiquement acceptables, des solvates ou des esters dudit composé, ou dudit promédicament, ledit composé ayant la structure générale illustrée dans la formule 1, ou un sel pharmaceutiquement acceptable, un solvate ou un ester de celui-ci. L'invention concerne également un procédé faisant appel à un composé de la formule 1 pour traiter des maladies induites par la chimiokine, par exemple une thérapie palliative, curative, prophylactique de certaines maladies et de certains états, par exemple des maladies inflammatoires (y compris, notamment, le psoriasis), des maladies auto-immunes (y compris, notamment, polyarthrite rhumatoïde, sclérose en plaques), le rejet de greffes (y compris, notamment, rejet de greffe allogénique, rejet d'hétérogreffe), les maladies infectieuses (par exemple la lèpre tuberculoïde), des éruptions médicamenteuses fixes, les réactions cutanées d'hypersensibilité retardée, l'inflammation ophtalmique, les diabètes de type I, la méningite virale et les tumeurs.
Anilkumar Gopinadhan N.
Hobbs Douglas W.
Kozlowski Joseph A.
Mcguinness Brian F.
Rosenblum Stuart B.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pharmacopeia Inc.
Schering Corporation
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