A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01)
Patent
CA 2411967
The present invention is directed to the site-specific PEGylation of immunoconjugates. In particular, the present invention provides immunoconjugates wherein a connector molecule attaching a targeting molecule to an effector molecule is conjugated to one or more polyethylene glycol molecules. The present invention further provides methods for increasing the antitumor activity of an immunotoxin, comprising attaching in a site-specific manner one or more polyethylene glycol molecules to a linker connecting a toxic moiety to a targeting moiety of an immunotoxin.
L'invention concerne la pegylation spécifique d'un site d'immunoconjugués, et en particulier des immunoconjugués dans lesquels une molécule de connexion, fixant une molécule de ciblage à une molécule effectrice, est conjuguée à au moins une molécule de polyéthylène glycol. L'invention concerne également des méthodes permettant d'augmenter l'activité antitumorale d'une immunotoxine, qui consiste à fixer de manière spécifique à un site au moins une molécule de polyéthylène glycol à un lieur qui connecte une fraction toxique à une fraction de ciblage d'une immunotoxine.
Kreitman Robert J.
Lee Byungkook
Nagata Satoshi
Onda Masanori
Pastan Ira H.
Sim & Mcburney
The Government Of The United States Of America As Represented By The Se Cretary Of The Departent Of Health And
LandOfFree
Pegylation of linkers improves antitumor activity and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pegylation of linkers improves antitumor activity and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pegylation of linkers improves antitumor activity and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1780494