C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12Q 1/04 (2006.01) G01N 33/15 (2006.01) G01N 33/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2757941
The present invention provides a therapeutic agent, for diseases in which neoplastic proliferation of plasma cells occurs, which is characterized by containing an anti-human CD48 monoclonal antibody and having cellular cytotoxicity to cells expressing human CD48; and the monoclonal antibody. In addition, the present invention provides a method for screening an active ingredient of a therapeutic agent for diseases in which neoplastic proliferation of plasma cells occurs, the method including the following processes: (1) a process of sorting a substance that binds specifically to human CD48; and (2) a process of sorting a substance having cellular cytotoxicity.
L'invention porte sur un agent thérapeutique pour des maladies dans lesquelles se produit une prolifération néoplasique de plasmocytes, lequel agent est caractérisé en ce qu'il comprend un anticorps monoclonal dirigé contre CD48 humain et ayant une activité cytotoxique sur des cellules qui peuvent exprimer CD48 humain. L'invention porte également sur l'anticorps monoclonal. L'invention porte en outre sur un procédé de criblage d'un ingrédient actif pour un agent thérapeutique pour des maladies dans lesquelles se produit une prolifération néoplasique de plasmocytes, lequel procédé comprend les étapes suivantes (1) et (2) : (1) sélection d'une substance capable de se lier spécifiquement à CD48 humain ; et (2) sélection d'une substance ayant une activité cytotoxique.
Hosen Naoki
Sugiyama Haruo
Kirby Eades Gale Baker
Osaka University
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