Mini-e1a genes and gene products

Details Mini-e1a genes and gene products Mini-e1a genes and gene products

C - Chemistry, Metallurgy

12

N

C12N 15/34 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) C12N 15/88 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2271721

The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini- E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.

La présente invention concerne des procédés et des compositions destinés à la suppression de transformations oncogènes, de l'oncogenèse et de métastases. Des domaines fonctionnels de E1A responsables de la suppression de transformations sont décrits, ainsi que des constructions de mini-E1A pouvant être utilisées dans la suppression de tumeurs. Sont également décrits des procédés destinés à l'utilisation nouvelle de mini-E1A en combinaison avec des médicaments chimiothérapeutiques et/ou des inhibiteurs de tyrosine kinase.

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