Pyridine derivatives and use thereof as urotensin ii...

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/4545 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2540196

The invention relates to novel pyridine derivatives of formula 1 and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and their use as neurohormonal antagonists, especially as urotensin II inhibitors.

L'invention concerne de nouveaux dérivés de pyridine de formule générale (1) et des composés associés, ainsi que leur utilisation comme principe actif lors de la préparation de compositions pharmaceutiques. L'invention concerne également des procédés pour la préparation desdits composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés, ainsi que leur utilisation comme antagonistes neurohormonaux, notamment comme inhibiteurs de l'urotensine II.

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