Epitope analogues

Details Epitope analogues Epitope analogues

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/00 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2612494

Some embodiments relate to analogs of peptides corresponding to class I MHC- restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

Certains modes de réalisation concernent des analogues de peptides correspondant aux épitopes de lymphocytes T classe I MHC restreints ainsi que des procédés permettant leur génération. Ces analogues peuvent contenir des substitutions aminoacides sur des restes qui réagissent directement avec des molécules MHC, et peuvent conférer des propriétés immunologiques améliorées, modifiées ou utiles. L'invention concerne en outre des classes d'analogues, dans lesquelles les diverses substitutions comprennent les restes non standards norleucine et/ou norvaline.

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