C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 271/10 (2006.01)
Patent
CA 2563615
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme is involved.
La présente invention concerne des dérivés de phényle 1,3,5-substitués qui sont des inhibiteurs de l'enzyme bêta-secrétase et qui sont utiles dans le traitement de maladies dans lesquelles la bêta-secrétase est impliquée, telles que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, ainsi que l'utilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles la bêta-secrétase est impliquée.
Barrow James C.
Coburn Craig A.
Mcgaughey Georgia B.
Nantermet Philippe G.
Rajapakse Hemaka A.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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