C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/02 (2006.01) A61K 31/7056 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2539032
The invention relates to glucopyranosyloxy-pirazoles of formula (I), wherein R1 to R6 and R7a, R7b and R7c are defined in the claim 1, to the tautomers, stereoisomers, mixtures and the salts thereof, in particular the salts which are physiologically compatible with inorganic or organic acids and exhibit interesting pharmacological properties, in particular inhibitor effect on a sodium-dependent SGLT glucose cotransporter. The use of the inventive compounds for treating diseases, in particular metabolic diseases such as diabetes and the production thereof are also disclosed.
L'invention concerne des pyrazoles glucopyranosyloxy de formule (I), dans laquelle R1 à R6 ainsi que R7a, R7b, R7c sont définis dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges et leurs sels, notamment les sels physiologiquement compatibles avec des acides inorganiques ou organiques ayant des qualités pharmacologiques intéressantes, notamment un effet inhibiteur sur le co-transporteur de glucose SGLT dépendant du sodium. La présente invention porte également sur leur utilisation dans le traitement de maladies, notamment des maladies du métabolisme telles que le diabète, et sur leur production.
Barsoumian Edward Leon
Eickelmann Peter
Himmelsbach Frank
Thomas Leo
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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