Surface expression of enzyme in gene directed prodrug therapy

Details Surface expression of enzyme in gene directed prodrug therapy Surface expression of enzyme in gene directed prodrug therapy

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 31/195 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12N 9/12 (2006.01) C12N 9/48 (2006.01) C12N 9/50 (2006.01)

Patent

CA 2196051

The invention provides a two component system for use in association with one another comprising: (a) a vector capable of expressing an enzyme at the surface of a cell; and (b) a prodrug which can be converted into an active drug by said enzyme, useful in the treatment of tumours.

Système à deux constituants destinés à être utilisés en association l'un avec l'autre, qui comprend (a) un vecteur capable d'exprimer une enzyme à la surface d'une cellule, et (b) un promédicament qui peut être converti en un médicament actif par ladite enzyme, utile dans le traitement des tumeurs.

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