The use of aryl-cyclohexylamine derivatives against cns...

Details The use of aryl-cyclohexylamine derivatives against cns... The use of aryl-cyclohexylamine derivatives against cns...

A - Human Necessities

61

K

A61K 31/335 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/13 (2006.01) A61K 31/137 (2006.01) A61K 31/138 (2006.01) A61K 31/18 (2006.01) A61K 31/357 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01)

Patent

CA 2280455

The present invention relates to the use of compounds of the general formula (see above formula) wherein Ar1 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonamide; Ar2 is phenyl, naphthyl or tetrahydronaphthyl, optionally substituted by lower alkyl or halogen; X is C, CH, C(OH) or N; Y is -CH2-, CH or O Z -CH2-, -CH(CH3)- or -C(CH3)2-; R1 is hydrogen, lower alkyl or acetyl; A its C=O or -(CHR2)n-, wherein R2 is hydrogen, lower alkyl or hydroxy-lower alkyl; B is -(CH2)n-, O, -CH(OH)(CH2)n-, -CH(CH2OH)(CH2)n-, -(CH2)nCH(OH)- or -CH(CH2OH)-; --- may be a bond and n is 0-4 and to pharmaceutically acceptable acid addition salts thereof for the manufacture of medicaments which represent therapeutic indications for NMDA receptor subtype specific blockers.

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