Treatment involving dkk-1 or antagonists thereof

Details Treatment involving dkk-1 or antagonists thereof Treatment involving dkk-1 or antagonists thereof

C - Chemistry, Metallurgy

12

N

C12N 5/20 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2438245

Antagonists to Dickkopf-1 (Dkk-1) proteins are administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin- dependent diabetes mellitus (NIDDM), hypoinsulinemia, and disorders involving muscle atrophy, trauma, or degeneration. Preferably, the antagonists are composed of compositions comprising antibodies directed to Dkk-1 in a pharmaceutically acceptable carrier for use in blocking the effects of Dkk-1. Additionally provided is a method of treating obesity or hyperinsulinemia in a mammal by administering an effective amount of Dkk-1 to a mammal. Also provided are methods of diagnosing insulin resistance, hyper- and hypoinsulinemia, obesity, and related disorders using Dkk-1 as a target and non-human transgenic animals that overexpress dkk-1 nucleic acid.

L'invention concerne un traitement consistant à administrer des antagonistes des protéines Dickkopf-1 (Dkk-1) en quantités efficaces pour traiter les troubles impliquant une résistance insulinique, tels que le diabète non insulino-dépendant (NIDDM), l'hypoinsulinémie et les troubles impliquant une atrophie musculaire, un traumatisme ou une dégénération. Ces antagonistes sont avantageusement composés d'anticorps dirigés contre Dkk-1 dans un excipient pharmaceutiquement acceptable et utilisés pour bloquer les effets de Dkk-1. L'invention concerne également une méthode de traitement de l'obésité ou de l'hyperinsulinémie chez un mammifère, consistant à administrer une quantité efficace de Dkk-1 à un patient. L'invention concerne également des méthodes permettant de diagnostiquer la résistance insulinique, l'hyper- et l'hypoinsulinémie, l'obésité et les troubles associés, à l'aide de Dkk-1 comme cible et des animaux transgéniques non humains surexprimant l'acide nucléique dkk-1.

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