Method of genotypically modifying cells by administration of...

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A61K 48/00 (2006.01) A61K 31/7105 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2595523

A method of inducing genotypic modification in a cell, which comprises providing isolated RNA comprising RNA extractable from source tissue to the cell under conditions whereby the desired induction of genotypic modification is achieved, wherein the RNA is isolated polyA positive RNA in substantially pure form.

La présente invention concerne un procédé d'induction d'une modification génotypique dans une cellule, qui consiste à fournir à la cellule de l'ARN isolé comprenant de l'ARN extractible du tissu source, dans des conditions permettant d'obtenir l'induction souhaitée de la modification génotypique, ledit ARN étant de l'ARN positif isolé polyA sous une forme pratiquement pure.

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