C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2635899
Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.
La présente invention concerne des composés répondant à la formule (I) et des sels pharmaceutiquement acceptables, dans laquelle X1, X2, X3, X4, X5, X6, X7, R1 et Q1 sont définis dans le présent document, qui inhibent des enzymes kinase et sont utiles dans le traitement et/ou la prophylaxie de pathologies hyperprolifératives, telles qu~un cancer. Les composés sont également utiles dans le traitement d~une inflammation, d~une allergie, de l~asthme, d~une pathologie et d~affections du système immunitaire, de pathologies et d~affections du système nerveux, de cardiopathies, de maladies et affections ophtalmiques, de pathologies dermatologiques, de l~ostéoporose, de diabètes, de la sclérose en plaque et d~infections.
Arnold Lee D.
Chen Xin
Dong Hanping
Garton Andrew
Krulle Thomas Martin
Cassan Maclean
Osi Pharmaceuticals Inc.
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