Processes of purifying oligonucleotides

Details Processes of purifying oligonucleotides Processes of purifying oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 1/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2449552

Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide to produce a purified oligonucleotide.

Cette invention concerne des procédés de préparation d'oligonucléotides purifiés consistant : à traiter une solution contenant un oligonucléotide au moyen d'un agent agrégant et d'un amplificateur de précipitations dans des conditions suffisantes pour former un agrégat d'oligonucléotides ; et à isoler l'oligonucléotide afin de produire un oligonucléotide purifié.

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