A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2534585
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
Cette invention concerne des anticorps qui interagissent avec ou se lient à un facteur de croissance du nerf (NGF) humain et neutralisent la fonction de NGF. Cette invention porte sur des compositions pharmaceutiques de ces anticorps et sur des procédés de neutralisation de la fonction de NGF, notamment pour traiter des troubles liés à NGF (par exemple la douleur chronique) par administration d'une quantité pharmaceutiquement efficace d'anticorps anti-NGF. L'invention porte également sur des procédés de détection de la quantité de NGF dans un échantillon au moyen d'anticorps anti-NGF.
Huang Haichun
Inoue Heather
Martin Frank
Treanor James J. S.
Wild Kenneth D. Jr.
Amgen Inc.
Gowling Lafleur Henderson Llp
Medarex Inc.
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