Methods and microorganisms for the production of...

C - Chemistry – Metallurgy – 12 – P

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C12P 13/02 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 15/03 (2006.01) C12N 15/52 (2006.01) C12P 7/42 (2006.01)

Patent

CA 2434518

The present invention features methods of producting 3-(2-hydroxy-3-methyl- butyrylamino)-propionic acid ("HMBPA") and .alpha.-hydroxyisovalerate (".alpha.-HIV") utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including .alpha.-HIV.

La présente invention concerne des procédés de production d'acide 3-(2-hydroxy-3-méthyl-butyrylamino)-propionique ("HMBPA") et d'.alpha.-hydroxyisovalérate (".alpha.-HIV") en utilisant des micro-organismes agissant comme des enzymes biosynthétiques modifiés de pantothénate. L'invention concerne également des micro-organismes de recombinaison et des états permettant leur culture. L'invention concerne enfin des compositions incluant le HMBPA ainsi que des compositions incluant le .alpha.-HIV.

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