Pharmacologically active amide carboxylate derivatives

Details Pharmacologically active amide carboxylate derivatives Pharmacologically active amide carboxylate derivatives

C - Chemistry, Metallurgy

07

C

C07C 233/47 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 233/49 (2006.01) C07C 233/51 (2006.01) C07C 235/12 (2006.01) C07C 237/22 (2006.01) C07C 259/06 (2006.01) C07C 323/59 (2006.01) C07C 323/60 (2006.01) C07C 323/63 (2006.01) C07D 213/70 (2006.01) C07D 233/84 (2006.01) C07D 239/38 (2006.01) C07D 277/30 (2006.01) C07D 285/125 (2006.01) C07D 307/91 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2072018

2072018 9108737 PCTABS00005 This invention relates to compounds having pharmacological activity, processes for their preparation, compositions containing them and methods of treatment involving their use. In its broadest aspect, the invention is concerned with compounds, having general formula (I) in which R1 represents an alkyl C1-18 group optionally substituted by an aryl group or hydroxy or a cycloalkyl C3-6 group, R2 represents an alkyl C1-18 group optionally substituted by an aryl group, or R2 represents a group -CH2-X-R4 wherein X represents O or S, and R4 represents hydrogen, an aryl group, or an alkyl or alkenyl C1-18 group optionally substituted by an aryl group, R3 represents OH, alkoxy C1-6 or -NHR31, wherein R31 represents hydrogen, alkyl C1-6, OH or alkoxy C1-6 optionally substituted by an aryl group, R5 represents hydrogen, an aryl group or an alkyl or alkenyl C1-18 group optionally substituted by an aryl group, n represents 0, 1, 2 or 3, p represents 0, 1 or 2, q represents 0 or 1, Y represents -CHR6-, -CH=CH-, O or S, in which R6 represents hydrogen, an aryl group or an alkyl or alkenyl C1-18 group optionally substituted by an aryl group, and pharmaceutically acceptable derivates thereof.

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