Compounds and compositions as protein kinase inhibitors

Details Compounds and compositions as protein kinase inhibitors Compounds and compositions as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01)

Patent

CA 2540518

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, lck, SAPK2.alpha., p38, TGF.beta., KDR, c-Kit, b- RAF, c-RAF, FLT1 and FLT4 kinases.

L'invention porte sur une nouvelle classe de composés, sur des compositions pharmaceutiques comprenant ces composés et sur leurs procédés d'utilisation dans le traitement ou la prévention de maladies ou troubles associés à une activité anormale des kinases, notamment des maladies ou troubles impliquant l'activation anormale des kinases Abl, BCR-Abl, PDGF-R, lck, SAPK2?, p38, TGF?, KDR, c-Kit, b-RAF, c-RAF, FLT1 et FLT4.

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