Cancerous disease modifying antibodies

Details Cancerous disease modifying antibodies Cancerous disease modifying antibodies

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 5/16 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2617458

The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.

L'invention se rapporte à une méthode permettant de produire des anticorps capables de modifier l'évolution d'une maladie cancéreuse chez un patient à l'aide d'un nouveau paradigme de criblage. Le procédé, qui consiste à isoler des anticorps anticancéreux en utilisant la cytotoxicité des cellules cancéreuses pour résultat final, permet de produire des anticorps anticancéreux destinés à un usage thérapeutique et diagnostique. On peut utiliser ces anticorps pour stadifier et diagnostiquer un cancer, et pour traiter des tumeurs primaires et des métastases tumorales. Ces anticorps anticancéreux peuvent être conjugués à des toxines, des enzymes, des composés radioactifs et des cellules hématogènes.

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