Improved process for the manufacture of...

Details Improved process for the manufacture of... Improved process for the manufacture of...

C - Chemistry, Metallurgy

07

C

C07C 43/174 (2006.01) C07C 41/16 (2006.01)

Patent

CA 2477862

The invention relates to an improved method for producing 4-(6-bromohexyloxy) butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst. 4-phenylbutanol is metered in a diluent to a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst, and a diluent. Also disclosed is the use of the resulting 4-(6-bromohexyloxy) butylbenzene for producing salmeterol in a previously known manner.

La présente invention concerne un procédé amélioré de production de 4-(6-bromohexyloxy)-butylbenzène, consistant à mettre en réaction du 4-phénylbutanol avec du 1,6-dibromohexane en présence d'une base et d'un catalyseur par transfert de phase. Selon ce procédé, du 4-phénylbutanol est dosé dans un agent de dilution jusqu'à l'obtention d'un mélange constitué d'1,6-dibromohexane, d'une base, d'un catalyseur par transfert de phase et d'un agent de dilution. Ladite invention concerne également l'utilisation du 4-(6-bromohexyloxy)-butylbenzène ainsi produit dans la production de salmétérol de manière connue en soi.

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