Aryl sulfonamides

Details Aryl sulfonamides Aryl sulfonamides

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07D 213/26 (2006.01) C07D 213/50 (2006.01) C07D 213/70 (2006.01) C07D 213/74 (2006.01) C07D 213/84 (2006.01) C07D 213/89 (2006.01) C07D 241/12 (2006.01)

Patent

CA 2500492

Compounds of formula (I) (in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

L'invention concerne des composés qui agissent comme puissants antagonistes du récepteur CCR9, et qui ont été en outre confirmés dans des essais animaux d'inflammation, un état pathologique caractéristique du CCR9. Les composés, d'ordinaire des dérivés d'arylsulfonamides, sont utilisés dans compositions pharmaceutiques, des procédés de traitement de maladies médiées par CCR9, et comme témoins dans des analyses d'identification d'antagonistes du CCR9.

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