Transplants

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/53 (2006.01) A01N 1/02 (2006.01) A61K 31/167 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2717162

The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent.

La présente invention porte sur un procédé de réduction d'une lésion à des cellules, un tissu ou un organe qui doit être explanté d'un corps et lors de l'implantation dans un corps par l'administration d'une composition aux cellules, au tissu ou à l'organe, comprenant : (i) un ouvreur ou agoniste des canaux potassiques et/ou un agoniste des récepteursde l'adénosine ; et (ii) un agent antiarythmique. L'invention concerne également une composition permettant de réduire une lésion au système vasculaire ex vivo, comprenant : (i) un ouvreur ou agoniste des canaux potassiques et/ou un agoniste des récepteurs de l'adénosine ; et (ii) un agent antiarythmique.

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