A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/09 (2006.01) A61K 38/24 (2006.01) C07K 7/00 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2435877
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. A useful antagonist is Acetyl-.beta.-[2-Napthyl]-D-Ala- D-p-Chloro-Phe-.beta.[3-Pyridyl]-D-Ala-Ser-N.epsilon.-[Nicotinoyl]-Lys- N.epsilon.[Nicotinoyl]-D-Lys-Leu-N.epsilon.-[Isopropyl]-Lys-Pro-D-Ala-NH2. Other useful antagonists are Nal-Glu, PPI-149 and acryline.
L'invention concerne un procédé permettant de réduire l'incidence ou de retarder l'apparition du diabète chez des mammifères sensibles au diabète (p. ex. la souris, le rat, l'homme), procédé selon lequel les mammifères sont traités avec un antagoniste de l'hormone à libération de la gonadotropine (GnRH). L'antagoniste est de préférence administré de façon répétée par injection sous-cutanée. Un antagoniste utile est l'Acétyl-.beta.-[2-Naphtyl]-D-Ala-p-Chloro-Phe-.beta.-[3-Pyridyl]-D-Ala-Ser-N.epsilon.-[Nicotinoyl]-Lys-N.epsilon.-[Nicotinyl]-D-lys-leu-n.epsilon.-[Isopropyl]-Lys-Pro-D-Ala-NH¿2?. D'autres antagonistes utiles sont Nal-Glu, PPI-149 et l'acryline.
Children's Mercy Hospital
Gowling Lafleur Henderson Llp
LandOfFree
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