Pharmaceutical composition for immunomodulation

Details Pharmaceutical composition for immunomodulation Pharmaceutical composition for immunomodulation

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2243559

Pharmaceutical composition containing at least one peptide or protein (fragment) with an immunomodulatory activity together with an adjuvant. The peptide is derived from a pathogenic agent or a tumour antigen. The adjuvant is capable of increasing the binding of the peptide to the cells of the individual to be treated or of increasing the entry of the peptide into the cells and strengthening the immunomodulatory activity of the peptide. Preferred adjuvants are basic polyamino acids such as polyarginine or polylysine, optionally conjugated with a cellular ligand such as a carbohydrate group or transferrin. The composition is particularly intended for use as a vaccine, e.g. as a tumour vaccine.

L'invention concerne une composition pharmaceutique contenant au moins un peptide à action immunorégulatrice ou une protéine(fragment), conjointement avec un adjuvant. Le peptide est dérivé d'un stimulant pathogène ou d'un antigène tumoral. L'adjuvant a la capacité d'augmenter la liaison du peptide aux cellules de l'individu à traiter ou d'augmenter l'entrée du peptide dans les cellules et d'entraîner un renforcement de l'action immunorégulatrice du peptide. Des adjuvants préférés sont des polyaminoacides basiques tels que la polyarginine ou la polylysine, qui sont éventuellement conjugués avec un ligand cellulaire, par ex. un reste d'hydrate de carbone ou de la transferrine. Cette composition s'utilise avant tout comme vaccin, par ex. comme vaccin tumoral.

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