Endoprosthesis, process to obtain and methods used

A - Human Necessities – 61 – F

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A61F 2/06 (2006.01) A61L 27/36 (2006.01) A61L 31/00 (2006.01) A61L 31/10 (2006.01) A61F 2/00 (2006.01) A61F 2/02 (2006.01)

Patent

CA 2506691

Comprising a wire mesh structure covered with biocompatible material and, more particularly, a substantially cylindrical expandable endoprosthesis (10) covered with biosynthetic cellulosic membrane for the treatment of arterial stenosis, where such structure is introduced in a mold (11), which is made of a material that is impermeable to liquids and permeable to gases, together with a culture medium (12) inoculated with a cellulose-producing microorganism such as the Acetobacter xylinum, resulting in the formation of a cellulosic membrane juxtaposed to the inner wall of said mold. The membrane can be impregnated to the inner wall of said mold (11). The membrane can be impregnated with therapeutic agents to be locally released during a period of days or weeks. Methods used to mount and deploy the endoprosthesis in the body.

L'invention concerne une endoprothèse comprenant une structure en treillis métallique recouverte d'un matériau biocompatible et, plus particulièrement, une endoprothèse (10) expansible essentiellement cylindrique recouverte d'une membrane cellulosique biosynthétique destinée au traitement de la sténose artérielle. La structure décrite dans cette invention est introduite dans un moule (11), lequel est constitué d'un matériau imperméable aux liquides et perméable aux gaz, conjointement avec un milieu de culture (12) dans lequel est inoculé un micro-organisme producteur de cellulose, tel que l'Acetobacter xylinum, ce qui a pour effet de déclencher la formation d'une membrane cellulosique juxtaposée à la paroi interne du moule. Cette membrane peut être enduite sur la paroi du moule (11). La membrane peut être enduite avec des agents thérapeutiques devant être libérés localement pendant un certain nombre de jours ou de semaines. La présente invention concerne également des procédés permettant de monter et de déployer l'endoprothèse dans le corps.

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