C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/351 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 411/12 (2006.01)
Patent
CA 2516239
The present invention relates to compounds having a general formula (I) and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.
La présente invention concerne des composés et leurs utilisations, notamment dans l'industrie pharmaceutique. L'invention divulgue des composés présentant des activités anti-proliférative et anti-angiogénique, ainsi que des procédés de traitement de différentes pathologies associées à une prolifération cellulaire anormale, dont le cancer, ou celles associées à une angiogenèse non régulée, comprenant la croissance et la métastase des tumeurs solides, des pathologies oculaires et notamment les rétinopathies, ou encore de l'arthrite, ledit traitement consistant à administrer lesdits composés. L'invention concerne également des compositions pharmaceutiques comportant lesdits composés et destinées notamment au traitement des cancers (tels que la leucémie), des pathologies oculaires et de l'arthrite.
Leblond Bertrand
Petit Silvere
Picard Virginie
Schweighoffer Fabien
Taverne Thierry
Exonhit Therapeutics Sa
Robic
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