Polymer coating for medical devices

Details Polymer coating for medical devices Polymer coating for medical devices

C - Chemistry, Metallurgy

09

D

C09D 183/08 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01) A61L 33/00 (2006.01) C09C 3/12 (2006.01) C09D 183/06 (2006.01) A61F 2/82 (2006.01)

Patent

CA 2672990

Coatings are provided in which surfaces may be activated by covalently bonding a combination ofsilane derivatives (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone polymer. Biologically active agents or therapeutic compounds may be deposited with any of the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.

La présente invention concerne des revêtements dans lesquels les surfaces peuvent être activées en liant de manière covalente une combinaison de dérivés silane (A) à la surface métallique, en liant de manière covalente un polymère lactone (B) au dérivé silane par une polymérisation par ouverture de cycle in situ, et en déposant au moins une couche d'un polyester (C) sur le polymère lactone lié. Des agents biologiquement actifs ou des composés thérapeutiques peuvent être déposés avec l'une quelconque des couches de polyester. De telles surfaces enduites peuvent être utiles dans des dispositifs médicaux, en particulier des endoprothèses vasculaires.

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