A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 10/00 (2006.01) A61B 5/00 (2006.01) A61B 8/00 (2006.01) A61K 41/00 (2006.01) A61B 17/22 (2006.01)
Patent
CA 2457589
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, and at least one intersystem crossing enhancing substituent to meso- or beta-positions of a porphyrin structure of the porphyrin-based photosensitizer, to thereby increase multi-photon absorption cross-section of the porphyrin-based photosensitizer to at least about 30 GM units at about its maximum wavelength for two-photon absorption. The TPA-chromophore is selected from a group of p-conjugated structures. The resulting porphyrin-based photosensitizer absorbs two photons of radiation in the range of about 700 nm to about 1300 nm. (Figure 2) discloses the molecular structures of three porphyrins.
L'invention concerne un procédé d'augmentation d'une section efficace d'absorption multi-photons d'un photosensibilisant à base de porphyrine en liant au moins un chromophore TPA à des méso- ou béta-positions d'une structure dudit photorésistant à base de porphyrine, et au moins une conversion intersystème améliorant le substituant placé à des méso- ou béta-positions d'une structure de porphyrine du photosensibilisant à base de porphyrine. Ceci permet d'augmenter une section efficace d'absorption multi-photons dudit photosensibilisant à base de porphyrine d'au moins 30 unités génétiquement modifiées à une longueur d'onde maximum pour l'absorption à deux photons. Le chromophore d'absorption à deux photons est sélectionné d'un groupe de structures .pi.-conjuguées. Le photosensibilisant à base de porphyrine résultant absorbe deux photons de radiation de l'ordre de 700 nm à environ 1300 nm. Les structures moléculaires de trois porphyrines font l'objet de la figure 2.
Nickel Eric
Rebane Aleksander
Spangler Charles W.
Gowling Lafleur Henderson Llp
Montana State University
LandOfFree
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