A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/21 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2705105
The invention relates to therapeutic compositions for the treatment of cancer and, more specifically, compositions containing an agonist ligand for receptor 4-1BB and a type-1 interferon, the simultaneous or sequential delivery of which results in a synergic antitumour effect in relation to the individual delivery of any of the components. The invention also relates to the therapeutic uses of the combinations of the invention for the treatment of cancer. The invention further relates to polynucleotides that code for compounds, vectors and cells containing same, as well as to the use thereof for the treatment of cancer.
La invención se relaciona con composiciones terapéuticas para el tratamiento del cáncer y, más concretamente, con composiciones que comprenden un ligando agonista del receptor 4-1BB y un interferón de tipo I cuya administración simultanea o secuencial resulta en un efecto antitumoral sinérgico con respecto a la administración de cualquiera de los componentes de forma individual. La invención se relaciona también con usos terapéuticos de las combinaciones de la invención para el tratamiento del cáncer. Por último la invención se relaciona con polinucleótidos que codifican para ambos compuestos, vectores y células que los comprenden así como su uso para el tratamiento del cáncer.
Dubrot Armendariz Juan
Hervas Stubbs Sandra
Le Bon Agnes Laurence
Melero Bermejo Ignacio Javier
Institut National de La Sante Et de La Recherche Medicale
Perry + Currier
Proyecto de Biomedicina Cima S.l.
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