Pharmaceutical composition containing 4-oxo-butynic acids

C - Chemistry – Metallurgy – 07 – C

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C07C 59/84 (2006.01) A61K 31/19 (2006.01) A61K 31/341 (2006.01) A61K 31/36 (2006.01) A61P 3/10 (2006.01) C07D 307/16 (2006.01) C07D 317/60 (2006.01)

Patent

CA 2263348

The invention concerns a pharmaceutical composition containing, as active principle, a compound of formula (a) in which groups A and B are selected independently of each other among: a mono-cyclic, bi- cyclic or tri-cyclic aryl group having 6 to 14 carbon atoms; a heteroaraomatic group selected among the pyridyl, pyrimidyl, pyrrolyl, furyl and thienyl groups; an alkyl group having 1 to 14 carbon atoms; a cycloalkyl group having 5 to 8 carbon atoms; a saturated heterocyclic group selected among the tetrahydrofuryl, tetrahydropyrranyl, piperidinyl and pyrrolidinyl groups; its solvate or a salt of this acid with a pharmaceutically acceptable base.

La présente invention concerne une composition pharmaceutique comprenant, à titre de principe actif, un composé de formule (I) dans laquelle les groupes A et B sont choisis indépendamment l'un de l'autre parmi: un groupe aryle mono-, bi- ou tricyclique ayant de 6 à 14 atomes de carbone; un groupe hétéroaromatique choisi parmi les groupes pyridyle, pyrimidyle, pyrrolyle, furyle et thiényle; un groupe alcoyle ayant de 1 à 14 atomes de carbone; un groupe cycloalcoyle ayant de 5 à 8 atomes de carbone; un groupe hétérocyclique saturé choisi parmi les groupes tétrahydrofuryle, tétrahydropyrranyle, pipéridinyle et pyrrolidinyle; son solvate ou un sel de cet acide avec une base pharmaceutiquement acceptable.

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