C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61K 31/44 (2006.01) A61P 19/00 (2006.01) A61P 35/00 (2006.01) C07D 213/82 (2006.01) C07D 237/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2434274
Selected compounds of formula (I), wherein each of A1 and A2 is independently C or N; wherein A1-A2 form part of a ring A selected from 5- or 6- membered heteroaryl; wherein X is; wherein Z is oxygen or sulfur; are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
L'invention concerne des composés choisis efficaces pour la prévention et le traitement de maladies, telles que les maladies induites par l'angiogenèse. L'invention concerne également de nouveaux composés, analogues, promédicaments et leurs dérivés pharmaceutiquement acceptables, des compositions pharmaceutiques ainsi que des méthodes de prévention et de traitement de maladies et d'autres états pathologiques, y compris le cancer et les maladies analogues. L'invention concerne en outre des procédés permettant de fabriquer lesdits composés ainsi que des intermédiaires utiles dans lesdits procédés.
Booker Shon
Cai Guolin
Chen Guoqing
Croghan Michael
Dipietro Lucian
Amgen Inc.
Gowling Lafleur Henderson Llp
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