Pharmaceutical composition with bisphosphonate

Details Pharmaceutical composition with bisphosphonate Pharmaceutical composition with bisphosphonate

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/663 (2006.01) A61P 19/00 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2720418

The present invention relates to depot formulations comprising a poorly water soluble salt of a bisphosphonate forming together with one or more biocompatible polymers, to poorly water- soluble salts of such bisphosphonates, to crystalline forms of the free compounds and the salts and to other related aspects, where the compounds are of the Formula (I), where R1 and R2 are as described in the specification. Compounds of the Formula (I) and their forms mentioned in the disclosure are useful for the treatment of bone-related disorders and cancer.

La présente invention porte sur des formulations retard comprenant un sel médiocrement soluble dans l'eau d'un bisphosphonate se formant conjointement avec un ou plusieurs polymères biocompatibles, sur des sels médiocrement solubles dans l'eau de tels bisphosphonates, sur des formes cristallines des composés libres et des sels et sur d'autres aspects apparentés, les composés étant représentés par la Formule (I), dans laquelle R1 et R2 sont tels que décrits dans le texte de la demande de brevet. Les composés de la Formule (I) et leurs formes mentionnées dans la description sont utiles pour le traitement de troubles liés à l'os et de cancer.

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