Naphthylene derivatives as cytochrome p450 inhibitors

Details Naphthylene derivatives as cytochrome p450 inhibitors Naphthylene derivatives as cytochrome p450 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61K 31/4192 (2006.01) A61P 35/00 (2006.01) C07C 211/19 (2006.01) C07D 249/04 (2006.01)

Patent

CA 2532078

Compounds of the formula (I); and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G 1,Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.

L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ces composés. Dans ladite formule, n1, n2, n3, n4, G?1¿, Q?1¿, Z, R?1¿, R?2¿, R?3¿, R?4a¿, R?4b¿, R?5a¿ et R?5b¿ sont tels que définis dans la description. Lesdits composés inhibent l'enzyme cytochrome P450RAI et sont utiles pour traiter et/ou prévenir divers états et maladies qui réagissent au traitement par les rétinoïdes et par l'acide rétinoïque d'origine naturelle.

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