C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/065 (2006.01) C07D 277/40 (2006.01)
Patent
CA 2106673
2106673 9218486 PCTABS00016 An improved process for the preparation of [1S-(1R*, 2S*, 3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1-_ cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide is described where the key intermediate, 3-(2-amino-4-thiazolyl)-L-alanine is converted without protecting the aminothiazole group to the desired compound, as well as valuable intermediates used in the process.
Belmont Daniel T.
Hendrickson Valerie
Hoekman Mark J.
Macrae & Co.
Warner-Lambert Company Llc
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