Beta-lapachone and s-phase drug combinations for cancer...

A - Human Necessities – 61 – K

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Details

A61K 31/352 (2006.01) A61K 31/7064 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2556759

Cancers and /or malignancies can be treated by administration of a G1/S phase drug, which is preferably .beta.-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, combined with an S phase drug, which is advantageously gemcitabine. This combination of a G1/S phase drug with an S phase drug results in an unexpectedly effective treatment of cancer. The invention includes methods of treating cancers by administering a combination of a G1/S phase drug and an S phase drug, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.

Des cancers et/ou des tumeurs malignes peuvent être traités par administration d'un médicament en phase G1/S, de préférence un .beta.-lapachone, ou un sel pharmaceutiquement acceptable, un promédicament, un métabolite, un analogue ou un dérivé de celui-ci, combiné avec un médicament en phase S, avantageusement de la gemcitabine. Cette combinaison d'un médicament en phase G1/S avec un médicament en phase S permet d'obtenir un traitement incroyablement efficace du cancer. Cette invention porte sur des procédés de traitement de cancers par administration d'une combinaison d'un médicament en phase G1/S et d'un médicament en phase S, sur des compositions pharmaceutiques contenant la combinaison de médicaments utilisés dans ces procédés, ainsi que sur des kits pharmaceutiques.

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