Phenyl-alkyl-imidazoles as h3 receptor antagonists

Details Phenyl-alkyl-imidazoles as h3 receptor antagonists Phenyl-alkyl-imidazoles as h3 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 233/64 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 233/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2309121

Disclosed are novel phenyl-alkyl-imidazoles of formula (I) wherein R1, R7, m, n, p, q, X, Y, Z, R and R15 are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Further disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines by administering compounds of formula (I). Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.

L'invention concerne de nouveaux phényl-alkyl-imidazoles de la formule (I) dans lesquels R?1¿, R?7¿, m, n, p, q, X, Y, Z, R et R?15¿ sont tels que définis dans la description. On décrit des compositions pharmaceutiques contenant les composés de la formule (I). On décrit en outre des procédés pour traiter une allergie, une inflammation, l'hypotension, le glaucome, les troubles du sommeil, l'hyper ou hypomotilité du tube digestif, l'hypo ou hyperactivité du système nerveux central, la maladie d'Alzheimer, la schizophrénie, l'obésité et les migraines par administration de composés de la formule (I). On décrit enfin des procédés pour traiter des réactions allergiques de la voie aérienne supérieure, qui consistent à administrer un composé de la formule (I) ou un sel ou solvate dudit composé, en combinaison ou convenablement mélangé avec un antagoniste du récepteur H¿1? à l'histamine.

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