Promotion of cell migration and axon regeneration in the cns

Details Promotion of cell migration and axon regeneration in the cns Promotion of cell migration and axon regeneration in the cns

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2583243

The present invention relates broadly to methods and compositions that promote migration of neural cells, or their extensions, from an originating region of the central nervous system to a second region in which, or at which, a need for such cells and/or their extensions has been identified. The method includes contacting a second neural cell with a composition that is effective to decorate the second neural cell with a hydrated polymer such as a polysaccharide. This second neural cell is located substantially within a zone of interest such as a second region; or the originating region; or a region of space that includes at least the originating region, the second region and a volume extending between them. The originating region includes any source of neural progenitor cells, or a source of outgrowth of neural cell projections such as axons or dendrites. The second region includes any region that is an intended destination for the promoted migration of progenitor or the extension of the neural cell projection, which may be a site diseased by a pathology or damaged by trauma. The invention further provides compositions useful to promote the migration of the CNS component cells or portions thereof.

L'invention concerne en règle générale des procédés et des compositions favorisant une migration des cellules neurales, ou des extensions de ces cellules, depuis une région d'origine du système nerveux central vers une seconde région dans laquelle on a identifié le besoin d'une présence de telles cellules et/ou de leurs extensions. On met en contact une seconde cellule neurale avec une composition efficace pour décorer la seconde cellule avec un polymère hydraté du type polysaccharide. Cette seconde cellule se trouve sensiblement dans une zone d'intérêt du type seconde région ; ou la région d'origine ; ou une région dont l'espace englobe au moins la région d'origine, la seconde région et un volume d'extension intermédiaire. La région d'origine s'entend de toute source de cellules neurales progénitrices, ou d'une source de croissance de projections cellulaires neurales du type axons ou dendrites. La seconde région s'entend de toute région qui est une destination visée pour la migration favorisée de cellules progénitrices ou l'extension de la projection cellulaire neurale, à savoir par exemple un site souffant d'une pathologie ou endommagé par un traumatisme. On décrit enfin des compositions utiles pour favoriser la migration de cellules constitutives du système nerveux central ou de parties correspondantes.

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