Composition for treating prostate cancer (pca)

Details Composition for treating prostate cancer (pca) Composition for treating prostate cancer (pca)

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2696772

The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate- Specific Antigen), PSMA (Prostate- Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.

La présente invention concerne une composition active (immunostimulante) comprenant au moins un ARN, de préférence un ARNm, codant pour au moins deux antigènes (de préférence différents) capables de déclencher une réponse immunitaire (adaptative) chez un mammifère, les antigènes étant choisis dans le groupe comprenant PSA (Antigène Spécifique de la Prostate), PSMA (Antigène de Membrane Spécifique de la Prostate), PSCA (Antigène de Cellule Souche de la Prostate) et STEAP (Antigène Epithélial Transmembranaire Six de la Prostate). L'invention concerne également un vaccin comprenant ladite composition active (immunostimulante), et l'utilisation de ladite composition active (immunostimulante) (pour la préparation d'un vaccin) et/ou du vaccin pour déclencher une réponse immunitaire (adaptative) pour le traitement du cancer de la prostate (PCa), de préférence de cancers de la prostate réfractaires aux néoadjuvants et/ou aux hormones, et des maladies ou troubles apparentés à ceux-ci. Enfin, l'invention concerne des coffrets, en particulier des coffrets de parties, contenant la composition active (immunostimulante) et/ou le vaccin.

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