Pharmaceutical lipid compositions

Details Pharmaceutical lipid compositions Pharmaceutical lipid compositions

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 47/14 (2006.01) A61K 47/22 (2006.01) A61K 47/30 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2595385

The present invention relates to a particulate composition containing; a) 5 to 90% of at least one phosphatidyl choline component b) 5 to 90% of at least one diacyl glycerol component, at least one tocopherol, or mixtures thereof, and c) 1 to 40% of at least one non-ionic stabilising amphiphile, where all parts are by weight relative to the sum of the weights of a+b+c and where the composition contains particles of at least one non-lamellar phase structure or forms particles of at least one non-lamellar phase structure when contacted with an aqueous fluid. The invention additionally relates to pharmaceutical formulations containing such compositions, methods for their formation and methods of treatment comprising their administration.

L'invention concerne une composition particulaire contenant: a) 5 à 90 % au moins d'un composant de phosphatidyl choline, b) 5 à 90 % au moins d'un composant de diacyl glycérol, au moins un tocophérol, ou des mélanges de ceux-ci, et c) 1 à 40 % au moins d'un amphiphile stabilisateur non ionique. Tous les pourcentages sont des pourcentages en poids par rapport à la somme des poids de a+b+c, et la composition contient des particules d'au moins une structure à phase non lamellaire ou forme des particules d'au moins une structure à phase non lamellaire, lorsqu'elle est mise en contact avec un fluide aqueux. L'invention concerne également des formulations pharmaceutiques contenant de telles compositions, des méthodes pour former ces formulations, et des méthodes de traitement consistant à administrer ces formulations.

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