A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/451 (2006.01) A61K 31/495 (2006.01) A61K 31/4965 (2006.01) A61P 1/16 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2453602
This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic hydroxamic acid, a derivative thereof, or a pharmaceutically acceptable salt of the hydroxamic acid or derivative to a host animal. The compound generally corresponds in structure to the following formula: , wherein W and the R groups are described in more detail in Applicants' specification.
L'invention concerne un procédé d'inhibition de l'activité de l'aggrécanase. Le procédé consiste à administrer une quantité efficace sur le plan thérapeutique d'un acide sulfonyl aromatique hydroxamique ou hétéroaromatique hydroxamique, un dérivé de celui-ci ou un sel acceptable sur le plan pharmaceutique de l'acide hydroxamique ou un dérivé à un animal hôte. Le composé correspond de manière générale structurellement à la formule suivante, dans laquelle W et les groupes R sont décrits plus en détails dans la description.
Arner Elizabeth
Barta Thomas A.
Becker Daniel P.
Boehm Terri L.
Decrescenzo Gary A.
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
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