Pyridinamide derivative as kinase inhibitors

Details Pyridinamide derivative as kinase inhibitors Pyridinamide derivative as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2557302

The invention relates to substituted arylamide derivatives of formula (I), to the production and use thereof for the production of a medicament for the treatment of diseases, in particular tumours and/or diseases which are provoked, transmitted and/or propagated by angiogenesis. Compounds of formula (I) are active inhibitors of tyrosine kinases, in particular TIE-2 and VEGFR, and the Raf-kinases.

L'invention concerne des dérivés arylamide substitués représentés par la formule (I), leur fabrication et leur utilisation dans la fabrication d'un médicament destiné au traitement de maladies, notamment de tumeurs et/ou de maladies provoquées, transmises et/ou propagées par l'angiogenèse. Les composés représentés par la formule (I) sont des inhibiteurs efficaces des tyrosine kinases, notamment de TIE-2 et de VEGFR, et des Raf-kinases.

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